FIBROCELLplus®

Otolog Fibroblast Hücresi ile kombine PRP & PRF

FIBROCELLplus®, FIBROCELL® ile aynı üretim platformunda üretilip, plateletten zengin plazma ile kombine edilerek, kapanmayan kronik yara (diyabet, bası, venöz ülser, poliarteritis nodosa vb.) ve yanıkların tedavisine yönelik kullanılan otolog hücresel tedavi yöntemidir.
FIBROCELLplus®, bağ dokunun ana hücreleri olan kişinin kendi fibroblast hücrelerinin yanı sıra, kişinin kendi kanından elde edilen plateletten zengin plazmayı da içermektedir.

Tedavi Prensibi

  • Bu iki ayrı otolog bileşen spesifik bir protokolle üretilip bir araya getirilir.
  • FIBROCELLplus® iyileşmeyen kronik yaraya uygulanarak buradaki epitelizasyon ve rejenerasyon sürecini başlatır.
  • FIBROCELLplus® doğal yoldan dermis iskeletinin oluşmasını sağlayarak granülasyon dokusunu destekler.

*FIBROCELLplus®, DOKU BİYOTEKNOLOJİ LTD.ŞTİ.’ye ait olup, Türkiye’deki ilk ve tek patentli otolog fibroblast hücre ile kombine PRP ürünüdür.

FIBROCELLplus Avantajları

  • Kişinin kendi dokusundan ve plazmasından elde edildiği (otolog) için yan etki oluşturmaz.
  • Biyouyumludur, doğaldır, sentetik veya kimyasal bileşenler içermez. Bu yönüyle skar doku oluşumunu da azaltır.
  • Hayvansal (sığır, domuz vb.) bileşenler içermez.
  • Kollajen, PGLA veya hyalüronik asit temelli sünger, membran veya jel formundaki biyomalzemelerle uyumlu çalışarak etkilerini artırır.
  • 3 tekrarlı uygulamadan oluşur. Bu yönüyle yara iyileşme sürecini destekler.

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Bilimsel Çalışmalar

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2- Alsousou, J., et al. The role of platelet-rich plasma in tissue regeneration. Platelets, 24:3, 173-182, 2013.

3- Scuderi, N.,  Anniboletti T. Clinical Application of Autologous Three-cellular Cultured Skin Substitutes Based on Esterified Hyaluronic Acid Scaffold: Our Experience.. In vivo  2009; 23: 991-1004.

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6- Ludena, D., et al. Cell culture in autologous fibrin scaffolds for applications in tissue engineering.  Experimental Cell Research.  322: 1-11, 2014.

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Han SK, Kim HS, Kim WK. Efficacy and safety of fresh fibroblast allografts in the treatment of diabetic foot ulcers. Dermatol Surg 2009; 35: 1342-8.

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16- Jeong SH, Han SK, Kim WK. Treatment of diabetic foot ulcers using a blood bank platelet concentrate. Plast Reconstr Surg 2010; 125: 944-52.

17- Han SK, Kim DW, Jeong SH, Hong YT, Woo HS, Kim WK, Gottrup F. Potential use of blood bank platelet concentrates to accelerate wound healing of diabetic ulcers. Ann Plast Surg 2007; 59: 532-7.

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20- Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler ELL. Classification and treatment of chronic nonhealing wounds: successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg 1986; 204: 322–30.

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