Autologous Fibroblast Cell Therapy

FIBROCELL® is an autologous treatment method based on the injection of fibroblast cells obtained from one’s own tissues into the region where one needs in a high-tech laboratory environment by bioengineering techniques.
FIBROCELL® is made up of person’s own fibroblast cells that produce the  constituent proteins of skin such as collagen, elastin and hyaluronic acid in the purest and natural way.
FIBROCELL® is manufactured personally for the treatment of chronic wounds, as well as for the removal of deep lines on the skin due to age-related aging, known in the media and in the provision of skin tissue regeneration.
FIBROCELL® is the first autologous cellular therapy approved by the FDA.

* FIBROCELL® belongs to DOKU BİYOTEKNOLOJİ CO. LTD. And it is the first and only registrated autologous fibroblast cell brand in Turkey.


3 adımda FIBROCELL

Physician, under local anesthesia , receives 1-2 pieces biopsies, preferably lentil size from behind the ear. Biopsy specimens with blood samples are placed in FIBROCELL® cold chain conveyor boxes and delivered to the DOKU Laboratory at 2-8 ° C.
In GMP approved zero particle laboratory with high technology system, the proliferation of millions of new fibroblast cells is ensured. This is done with the FDA approval within critical processes specific to FIBROCELL® production technology. The produced fibroblast cells are ready for implementation through the quality control processes specified by the Ministry of Health and the European Standard.
The patient comes to the clinic then, the skin is numbed with topical anesthetic creams. FIBROCELL® is injected into the desired area of the patient. FIBROCELL® application consists of 3 sessions. The first session will be ready after about 4-6 weeks after the biopsy, second and third of the sessions are conducted with intervals of 2-3 weeks. The effect of FIBROCELL starts at second month and continues increasingly. According to the research, it has been shown the activity continues up to 5 years.


  • It is produced personally, so the risk of allergy is minimal.
  • It is a FDA-approved cellular therapy.
  • It is permanent and long lasting.
  • There is no risk of animal disease.
  • It is elastic enough.
  • It does not contain botox or a filling material components, it is pure cell solution.
  • It does not create an apperance that can cause changes in mimics or face expressions.


  • In eliminating the wrinkles in the skin,
  • In whitening of the stains and dark areas,
  • In the treatment of festering chronic sores (diabetes, compression, venous ulcer, etc.)
  • Face renewal can be done with mesoteraphy (Facial rejuvenation) applications,
  • In filling the gaps which occur after disorders such as acne or chicken pox,
  • In the treatment of burns, past surgery or trauma-related cavities and nevas,
  • in plumping the lips,
  • in indirect baldness therapy
  • in periodontal applications in dentistry

Brochure & Link

Scientific Studies

  1. Mehrabani D, Manafi N. Role of Cultured Skin Fibroblasts in Aesthetic and Plastic Surgery. World J Plast Surg. 2013;2(1): 2-5.
  2. Weiss, R.A. Autologous cell therapy: Will it replace dermal fillers? Fac. Plast. Surg. Clin.N. Am. 2013, 21, 299–304.
  3. Morimoto, N.; Saso, Y.; Tomihata, K.; Taira, T.; Takahashi, Y.; Ohta, M.; Suzuki, S. Viability and function of autologous and allogeneic fibroblasts seeded in dermal substitutes after implantation. J. Surg. Res. 2005, 125, 56–67.
  4. Smith, S.R.; Munavalli, G.; Weiss, R.; Maslowski, J.M.; Hennegan, K.P.; Novak, J.M.A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol. Surg. 2012, 38, 1234–1243.
  5. Wisser, D.; Steffes, J. Skin replacement with a collagen based dermal substitute, autologous keratinocytes and fibroblasts in burn trauma. Burns 2003, 29, 375–380.
  6. Boss, W.K., Jr.; Usal, H.; Fodor, P.B.; Chernoff, G. Autologous cultured fibroblasts: A protein repair system. Ann. Plast. Surg. 2000, 44, 536–542.
  7. Watson, D.; Keller, G.S.; Lacombe, V.; Fodor, P.B.; Rawnsley, J.; Lask, G.P. Autologous fibroblasts for treatment of facial rhytids and dermal depressions. A pilot study. Arch. Fac. Plast. Surg. 1999, 1, 165–170.
  8. Weiss, R.A.; Weiss, M.A.; Beasley, K.L.; Munavalli, G. Autologous cultured fibroblast injection for facial contour deformities: A prospective, placebo-controlled, Phase III clinical trial.Dermatol. Surg. 2007, 33, 263–268.
  9. Munavalli, G.S.; Smith, S.; Maslowski, J.M.; Weiss, R.A. Successful treatment of depressed,distensible acne scars using autologous fibroblasts: A multi-site, prospective, double blind, placebo-controlled clinical trial. Dermatol. Surg. 2013, 39, 1226–1236.
  10. Eca, L.P.; Pinto, D.G.; de Pinho, A.M.; Mazzetti, M.P.; Odo, M.E. Autologous fibroblast culture in the repair of aging skin. Dermatol. Surg. 2012, 38, 180–184.
  11. Zhang, X.; Deng, Z.; Wang, H.; Yang, Z.; Guo, W.; Li, Y.; Ma, D.; Yu, C.; Zhang, Y.; Jin, Y.Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration. Biomaterials 2009, 30, 2666–2674.
  12. Boss WK Jr, Usal H, Fodor PB, Chernoff G. Autologous cultured fibroblasts: a protein repair system. Ann Plast Surg 2000 May;44:536–42.
  13. Robert A. Weiss; Margaret A. Weiss; Karen L. Beasley; Girish Munavalli. Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, Phase III clinical trial, 2007 Dermatol Surg 2007;33:263–268.
  14. Wong T, McGrath JA, Navsaria H. The role of fibroblasts in tissue engineering and regeneration. Br J Dermatol 2007; 156:1149-1155.
  15. Solakoglu S, Tiryaki T, Ciloglu SE. The effect of cultured autologous fibroblasts on longevity of cross-linked hyaluronic acid used as a filler. Aesthetic Surg J 2008; 28: 412-416.
  16. Nilforoushzadeh MA, Siadat AH, Arianrad M, Moulavi F, Baradaran EH, Esfahani MHN. Soft tissue augmentation by autologous cultured fibroblasts transplantation for treatment of wrinkles and scars: a case series of 20 patients. J Res Med Sci 2010; 15: 167-171.
  17. Eça LP, Pinto DG, De Pinho AMS, Mazzetti MPV, Odo MEY. Autologous fibroblast culture in the repair of aging skin. Dermatol Surg 2012; 38: 180-184.
  18. Bassetto F, Turra G, Salmaso R, Lancerotto, Del Vecchio DA. Autologous injectable dermis: a clinical and histological study. Plast Reconstr Surg 2013; 131: 589-596
  19. Ferguson PC, Boynton EL, Wunder JS, Hill RP, O’Sullivan B, Sandhu JS, Bell RS. Intradermal injection of autologous dermal fibroblasts improves wound healing in irradiated skin. J Surg Res 1999; 85: 331-338.
  20. Karchilaki I, Topakas G, Castana O, Sotiriou P, Michelakis D, Giokas CS. The use of cultured autologous fibroblasts in burn wounds healing process. Burns 2007; 33: 791-792.
  21. Kim JE, Lee OS, Choi J, Son SW, Oh CH. The efficacy of stereoimage optical topometry to evaluate depressed acne scar treatment using cultured autologous fibroblast injection. Dermatol Surg. 2011; 37:1304-13.
  22. Mc Guire MK, Scheyer ET: A randomized, double-blind, placebo controlled study to determine the safety and efficacy of cultured and expanded autologous fibroblast injections for the treatment of interdental papillary insufficiency associated with the papilla priming procedure. J Periodontol 2007;78:4-17.
  23. Nolte SV, Xu W, Rennakampff HO, Rodemann HP: Diversity of fibroblasts a review on implications for skin tissue engineering. Cells Tissue Organs 2008;187:165-76.